The next generation of protein interaction assays
Schedule a Free ConsultationNext Generation Interaction Screening and Mapping (NGIS) Services for Protein-Protein Interactions
Protein-protein interactions fundamentally underlie the function of biological systems.
What is a protein-protein interaction or PPI?
Protein–protein interactions are the physical contacts of high specificity established between two or more protein molecules.
Why measuring protein-protein interactions matters? Measuring protein-protein interactions is central to understanding the biological basis of disease and for enabling biotechnology to produce products ranging from safer and more effective therapeutics to next-generation foods, materials, and fuels.
Next Interactions, Inc. is a proteomics services company that delivers more complete, sensitive, and precise measurements of protein-protein interactions. Our Next Generation Interaction Screening and Mapping platform technology (NGIS) combines yeast two hybrid with next generation sequencing (NGS-Y2H), bringing conventional yeast two hybrid to the level of mass spectrometry approach. Our NGIS platform integrates the latest innovations in sequencing, yeast-based protein interaction mapping techniques, and quantitative cell-based reporters. Using cloud-based data delivery, our quantitative protein-protein interaction screens give scientists information-rich data sets with visualizations and bioinformatics analyses that are clear and actionable.
Our goal is to bring the most reliable and comprehensive tool to answer your protein interactions questions, whether screening for novel protein interactions for basic research or in search of a new drug target, or precision mapping of known functional interactions, or compound screening. Ultimately, we accelerate the R&D process for you, save you time & money and get you the results you need.
Protein Interaction Screening Challenges
Understanding protein interactions can be powerful, but conventional protein interaction screens needed to be improved. Why?
Interaction Coverage
Complete coverage of the interaction space requires analyzing thousands of interaction pairs.
Quantitation
Quantitative measurements are needed to assess the significance of the results.
Precision
Conventional Y2H results in too many false positives. Repetition of screens and background controls for statistical rigor reduces false positives.
Data Visualization
Effective visualization is required to analyze quantitative and comprehensive results.
Consult our Protein Interaction Screening Experts.
Contact Next Interactions for advice from our scientists about the best approach for elucidating the protein interactions you need to understand for your research. We can advise you on methods such as the NGS-yeast two-hybrid system, yeast two-hybrid system, how to compliment interactome coverage by mass spectrometry, and more.
We Take the Yeast Two-Hybrid System to the NextGen So You Don’t Miss an Interaction
Streamlined Experimental Screening Tools
Quantitative scoring and comparison to controls reduce false positives.
Cloud-Based Data
Visualization and Display
Access your data anywhere, any time, using our secure data sharing portal.
Advanced Bioinformatics
Tools for Data Analysis
Bioinformatics data analysis provides quantitative statistics.
Applications
Understanding of Inheritable Disease
With NGS–Yeast Two-Hybrid assays, find variants of unknown significance using parallel interaction fingerprints.
Novel Therapeutic Target Discovery
Generate interaction profiles for novel isoforms and protein variants.
Interactome-Driven Bioengineering
Support a protein interaction-driven rationale for protein engineering and synthetic biology.
Biotherapeutics Development
Explore the molecular mechanisms in pathogenesis.
Understanding of Inheritable Disease
With NGS–Yeast Two-Hybrid assays, find variants of unknown significance using parallel interaction fingerprints.
Novel Therapeutic Target Discovery
Generate interaction profiles for novel isoforms and protein variants.
Interactome-Driven Bioengineering
Support a protein interaction-driven rationale for protein engineering and synthetic biology.
Biotherapeutics Development
Explore the molecular mechanisms in pathogenesis.
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