The Next Generation of Protein Interaction Assays
Next-generation interaction screening (NGIS) is a reinvention of the yeast two-hybrid (Y2H) system that enables a comprehensive and precise identification of individual protein interactions and entire interaction networks.
Basic Research
Discovery of new PPIs, predict protein function, and compare interaction profiles for multiple proteins and protein isoforms.
Agri-Biosciences
Explore large PPI networks and pathways in different species, enabling thorough analysis of host-pathogen interactions.
Drug Discovery
Facilitate the discovery of novel drug targets and define mechanisms relevant for disease.
“Next Interaction’s NGIS screening with mutant and wild-type version of a gene implicated in hearing disorders revealed distinct interactions that may underlie observed phenotypes. These initial findings were crucial to our current research.”
Our Services
Find
Find novel protein-protein interactions with a comprehensive screening method: NGIS Yeast Two-Hybrid.
Chart
Chart entire interactome networks and pathways with high-throughput next-gen interaction screening: HTP-NGIS.
Map
Map protein binding domains at amino-acid resolution: Protein Domain Mapping using Yeast 2 Hybrid-Next Generation Sequencing: DoMySeq.
Test
Test protein interactions in one-on-one confirmation assays or perform conventional Y2H.
Our offer also include the synthesis of customized cDNA libraries for your in-house Y2H screens and support for downstream data analysis.
Press Release
A collaboration with BASF’s Agricultural Solutions division: HTP-NGIS was applied to uncover targets of Asian Soybean Rust effector proteins in its host plant.
Next Interactions and BASF Agricultural Solutions developed new technology to analyze Asian soybean rust 
Streamlined Screening Tools
Quantitative scoring and comparison to controls reduce false positives.
Advanced Bioinformatics
Quantitative scoring to reduce false positives.
Platform
Cloud-Based Data
Visualization and Display
Our Partners
